Showing posts with label Evidence Based Medicine. Show all posts
Showing posts with label Evidence Based Medicine. Show all posts

Wednesday, September 18, 2013

In a forthcoming review article from Nutrition and Cancer: An International Journal, researchers review available evidence that links orange juice with cancer chemoprevention.

File:Oranges and orange juice.jpg
Image Source  :  Wikimedia . Org
Sourcehttp://www.ars.usda.gov/is/graphics/photos/k7237-8.htm
AuthorUSDA photo by Scott Bauer. Image Number K7237-8.
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Can Drinking Orange Juice Aid in Cancer Prevention?

Sep. 13, 2013 — In a forthcoming review article from Nutrition and Cancer: An International Journal, a publication of Routledge, researchers review available evidence that links orange juice with cancer chemoprevention. The review article, "Orange Juice and Cancer Chemoprevention" discusses the putative mechanisms involved in the process, the potential toxicity of orange juice, and the available data in terms of evidence-based medicine.
Orange juice has many potential positive effects when it comes to cancer, particularly because it is high in antioxidants from flavonoids such as hesperitin and naringinin. Evidence from previous in vitro studies has indicated that orange juice can reduce the risk of leukemia in children, as well as aid in chemoprevention against mammary, hepatic, and colon cancers. Biological effects of orange juice in vitro are largely influenced by the juice's composition, which is dependent on physiological conditions of the oranges such as climate, soil, fruit maturation, and storage methods post-harvest.
The researchers acknowledge potential toxicity from orange juice if consumed in excess amounts -- especially for children, hypertensive, kidney-compromised, and diabetics. Excessive drinking of orange juice for individuals from these groups has the potential to create noxious effects, hyperkalemia, and has been associated with both food allergies and bacterial outbreaks in cases where the juice was unpasteurized. "Excessive intake of any food, even for the healthiest, can lead to oxidative status imbalance," wrote the researchers.
Further research is highly recommended to determine the biological connection between orange juice and cancer chemoprevention. Issues such as the type of cultivar and the amount consumed will also need clarification.
Overall, the review article summarizes several biological effects of orange juice that can contribute to chemoprevention, including antioxidant, antimutagenic and antigenotoxic, cytoprotective, hormonal, and cell signaling modulating effects. Orange juice has antimicrobial and antiviral action and modulates the absorption of xenobiotics. "OJ could contribute to chemoprevention at every stage of cancer initiation and progression," the researchers explained. "Among the most relevant biological effects of OJ is the juice's antigenotoxic and antimutagenic potential, which was shown in cells in culture and in rodents and humans."
Story Source:
The above story is based on materials provided by Taylor & Francis, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:
  1. Silvia Isabel Rech Franke, Temenouga Nikolova Guecheva, João Antonio Pêgas Henriques, Daniel Prá. Orange Juice and Cancer Chemoprevention. Nutrition and Cancer, 2013; : 130806112113004 DOI: 10.1080/01635581.2013.817594
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Saturday, August 10, 2013

Scientists who have done extensive research on the topics of immunization and autoimmune disorders have produced a new paper discusses why HPV Vaccines Are Unsafe

 

Scientists Explain Why HPV Vaccines Are Unsafe

August 8, 2013 | By   

WIKI-Gardasil-Jan ChristianHeidi Stevenson, Guest
Waking Times
There is no evidence that Gardasil or Cervarix can prevent cancer better than a decent screening program. There is strong evidence that they can produce severe and life-threatening harm. This report by 4 scientists documents how science has been corrupted & misused to promote these life-devastating vaccines.

Scientists who have done extensive research on the topics of immunization and autoimmune disorders have produced a new paper concluding that:
[P]hysicians should remain within the rigorous rules of evidence-based medicine, to adequately assess the risks versus the benefits of HPV vaccination.
In the context of the paper, it’s quite clear that they are saying the evidence does not support a positive risk-benefit ratio for the human papilloma virus (HPV) vaccines, Gardasil and Cervarix.

Ovarian Failure

The paper starts by discussing three cases of young women, studied by the authors, whose development had been quite normal, yet who experienced ovarian failure after receiving HPV vaccinations. They were studied extensively and all other potential causes were ruled out, leaving only the vaccines as the causative agent. They also point out another well-documented case similar to the ones they had investigated.
These are “only” four young women whose lives have been devastated, but the methods of treating girls who are recently post-menarchal is now to give them hormonal drugs, which can mask the symptoms of ovarian failure. The truth is that we do not know how many have been affected this way, and very likely won’t know for years.
These cases are then compared with the newly-described syndrome, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which can be characterized by the existence of several criteria. All of the girls fit the definition. Following is a copy of the table that displays which of the symptoms each young woman suffered:

 photo POF-Victims-ASIA-Symptoms_zpsa9b62527.jpg

Notice that a positive diagnosis for ASIA requires that the individual suffer from at least two major, or one major and two minor, symptoms. All three of these young women suffered from the vaccine-induced ASIA syndrome.
ASIA conditions include Gulf War syndrome, macrophagic myofasciitis, chronic fatigue syndrome, and silicone implant-induced autoimmunity (primarily from silicone breast implants).
The authors point out that the ASIA symptoms:
… are all too easily ignored or disregarded as irrelevant and non-vaccine related not only by patients and physicians, but also by scientists involved in design of vaccine trials. Nonetheless, many ill-defined medical conditions that fall under the ASIA spectrum are frequently disabling and thus of significant clinical relevance.
In other words, although far too many clinicians, doctors, and researchers ignore ASIA symptoms, calling them “irrelevant and non-vaccine related”, the fact is that they most assuredly are associated with severely disabling conditions.

HPV Vaccines and Autoimmune Disorders

The paper then goes on to discuss HPV vaccines and autoimmunity. They point out that the literature currently documents:
… numerous cases substantiating the link between adverse immune reactions and HPV vaccines, including fatal reactions.
They cite the case of a teenage girl who suffered dizziness, paresthesia, memory lapses, excessive tiredness, night sweats, loss of ability to use common objects, intermittent chest pain, and sudden racing heart after HPV vaccination. She died suddenly six months after the third Gardasil vaccination. The autopsy was unable to identify any toxicological, microbiological, or anatomical cause of death. However, investigations by a researcher showed that blood and spleen had been contaminated with HPV-16 L1 gene DNA fragments, which corresponded with ones fragments found in Gardasil vaccine vials from different lots. The authors conclude:


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