Posted on:
Thursday, July 25th 2013 at 8:30 am
Written By:
Sayer Ji, Founder
The study was titled, "Comparison of therapeutic effects of garlic and d-penicillamine in patients with chronic occupational lead poisoning," and sought to confirm previous research in animals that showed garlic (Allium sativum) is effective in reducing blood and tissue lead concentrations.[1]
The study took the measurements of the blood lead concentrations of 117 workers at a car battery plant who were randomly assigned to two groups of garlic (1.2 milligrams of allicin from approximately 1,000 mg of garlic extract, three times daily) and d-penicillamine (250 mg, three times daily) and treated for 4 weeks. Clinical signs and symptoms of lead poisoning were also investigated and compared with the initial findings.
The study found:
Clinical improvement was significant in a number of clinical manifestations including irritability (p = 0.031), headache (p = 0.028), decreased deep tendon reflex (p=0.019) and mean systolic blood pressure (0.021) after treatment with garlic, but not d-penicillamine. BLCs [blood lead concentrations] were reduced significantly (p=0.002 and p=0.025) from 426.32±185.128 to 347.34±121.056μg/L and from 417.47±192.54 to 315.76±140.00μg/L in the garlic and d-penicillamine groups, respectively, with no significant difference (p=0.892) between the two groups. The frequency of side effects was significantly (p=0.023) higher in d-penicillamine than in the garlic group. Thus, garlic seems safer clinically and as effective as d-penicillamine. Therefore, garlic can be recommended for the treatment of mild-to-moderate lead poisoning.Clearly, despite the near equal reduction in measurable blood lead concentrations in both groups, improvements in various measured clinical manifestations were only found in the garlic group. Also, side effects were higher in the d-penicillamine group. These results clearly indicate the superiority of garlic over the drug and underscore how drug-based interventions often end up 'normalizing' target values, e.g. blood lead concentrations, without resulting in improvement in the quality of life or even the objective clinical signs and subjective symptoms of the treated patient; to the contrary, often the patient feels and is much worse off following drug treatment.
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